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Secretoneurin biomarker
Secretoneurin (SN) is a circulating blood biomarker associated with cardiovascular disease, including acute heart failure. Clinical studies have shown that secretoneurin provides incremental prognostic information in cardiovascular disease.
Clinical relevance
Provides prognostic information independent of established cardiac biomarkers, including NT‑proBNP and hs‑Troponin
Associated with clinical outcomes across cardiovascular disease
High circulating SN has in several independent clinical observation studies been associated with poor outcome in patients
Reflects a distinct pathophysiological pathway: CaMKIIδ inhibition and cardiomyocyte calcium handling
What is secretoneurin?
Secretoneurin (SN) is a 33‑amino acid peptide derived from secretogranin II, and expressed in neuroendocrine tissues and the myocardium. It is detectable in the bloodstream and associated with cardiovascular pathophysiological processes, making it a practical and accessible blood-based biomarker for clinical use and translational research.
Key Properties
Origin
Secretogranin II (SgII)
Secretogranin II (SgII)
Structure
33 amino acid neuropeptide
33 amino acid neuropeptide
Source
Neuroendocrine & heart muscle cells
Neuroendocrine & heart muscle cells
Detection
Circulating in blood
Circulating in blood
Publications
© 2026
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© 2026