New review highlights prognostic and mechanistic roles of secretoneurin in cardiovascular disease
A review published in Expert Review of Cardiovascular Therapy discusses the emerging role of secretoneurin as a potential prognostic biomarker in cardiovascular disease. The authors report that circulating secretoneurin levels may provide prognostic information beyond established cardiovascular biomarkers.
The review highlights that these findings support the potential of secretoneurin in cardiovascular risk assessment, although its clinical utility and specific applications remain to be established.
In addition, the article summarizes experimental and preclinical evidence linking secretoneurin to several pathophysiological pathways relevant to cardiovascular disease.
Overall, the authors emphasize that secretoneurin is a promising biomarker with both prognostic and mechanistic relevance, but that further studies are needed to clarify its biological role and determine its value in clinical practice.
For CardiNor, the review reinforces the growing scientific interest in secretoneurin and the importance of reliable biomarker measurements in cardiovascular research.
Figure adapted from Ottesen et al. (2026), Expert Review of Cardiovascular Therapy. Modified for clarity and visual presentation.
Link to review article:
https://www.tandfonline.com/doi/full/10.1080/14779072.2025.2604574
![](data:image/svg+xml,<svg display="block" role="presentation" viewBox="0 0 117 29" xmlns="http://www.w3.org/2000/svg"><path d="M 0 23.377 L 0 6.474 L 2.03 6.474 L 2.03 23.377 Z M 0 2.877 L 0 0 L 2.03 0 L 2.03 2.877 Z M 12.275 23.802 C 7.331 23.802 4.581 19.976 4.581 14.941 C 4.581 9.906 7.397 6.081 12.308 6.081 C 16.04 6.081 18.56 8.108 19.117 11.574 L 17.087 11.574 C 16.596 9.056 14.927 7.781 12.308 7.781 C 8.412 7.781 6.677 11.018 6.677 14.941 C 6.677 18.865 8.445 22.069 12.275 22.069 C 15.156 22.069 16.956 20.271 17.284 17.557 L 19.215 17.557 C 18.822 21.382 16.302 23.802 12.275 23.802 Z M 20.565 8.631 L 20.565 6.474 L 23.02 6.474 L 23.02 1.144 L 25.672 1.144 L 25.672 6.474 L 28.946 6.474 L 28.946 8.631 L 25.672 8.631 L 25.672 19.617 C 25.672 20.794 26.294 21.186 27.374 21.186 C 27.898 21.186 28.487 21.055 28.782 20.957 L 28.88 20.957 L 28.88 23.246 C 28.258 23.377 27.538 23.475 26.752 23.475 C 24.591 23.475 23.02 22.592 23.02 20.205 L 23.02 8.631 Z M 44.975 23.54 C 43.24 23.54 42.323 22.755 42.062 21.023 L 42.029 21.023 C 41.014 22.33 39.279 23.703 36.398 23.703 C 33.19 23.703 30.669 22.2 30.669 18.995 C 30.669 15.007 33.812 14.189 38.035 13.536 C 40.425 13.176 42.094 12.947 42.094 11.116 C 42.094 9.22 40.719 8.141 38.297 8.141 C 35.547 8.141 34.172 9.318 34.074 11.868 L 31.519 11.868 C 31.617 8.599 33.778 6.147 38.263 6.147 C 41.864 6.147 44.516 7.487 44.516 11.508 L 44.516 19.551 C 44.516 20.924 44.843 21.676 46.317 21.349 L 46.415 21.349 L 46.415 23.278 C 46.087 23.409 45.662 23.54 44.974 23.54 Z M 36.987 21.676 C 40.523 21.676 42.127 19.094 42.127 17.132 L 42.127 14.255 C 41.243 14.811 39.704 15.236 38.264 15.497 C 35.612 15.988 33.484 16.445 33.484 18.93 C 33.484 21.186 35.252 21.676 36.987 21.676 Z M 51.024 6.474 L 51.024 9.285 L 51.089 9.285 C 52.104 7.651 53.872 6.277 56.131 6.277 C 56.622 6.277 56.884 6.343 57.211 6.474 L 57.211 9.024 L 57.113 9.024 C 56.72 8.893 56.458 8.86 55.934 8.86 C 53.315 8.86 51.024 10.822 51.024 13.993 L 51.024 23.377 L 48.372 23.377 L 48.372 6.474 Z M 65.698 29 C 61.311 29 58.823 27.234 58.529 24.325 L 60.984 24.325 C 61.246 26.188 63.014 26.908 65.633 26.908 C 68.743 26.908 70.478 25.502 70.478 22.559 L 70.478 20.172 L 70.412 20.172 C 69.168 21.775 67.826 22.788 65.404 22.788 C 61.017 22.788 58.005 19.29 58.005 14.418 C 58.005 9.154 61.311 6.081 65.24 6.081 C 67.695 6.081 69.267 7.029 70.412 8.631 L 70.478 8.631 L 70.478 6.474 L 73.13 6.474 L 73.13 22.461 C 73.13 26.908 70.183 29 65.698 29 Z M 65.535 20.565 C 69.43 20.565 70.674 17.851 70.674 14.287 C 70.674 10.593 69.103 8.304 65.502 8.304 C 62.326 8.304 60.722 10.789 60.722 14.451 C 60.722 18.145 62.392 20.565 65.535 20.565 Z M 83.965 23.834 C 78.792 23.834 75.781 19.846 75.781 14.941 C 75.781 10.037 78.989 6.048 83.801 6.048 C 88.876 6.048 91.593 9.972 91.593 15.563 L 78.498 15.563 C 78.694 18.995 80.56 21.611 83.965 21.611 C 86.42 21.611 88.057 20.434 88.646 18.145 L 91.233 18.145 C 90.447 21.775 87.795 23.834 83.965 23.834 Z M 83.801 8.141 C 80.658 8.141 78.956 10.495 78.563 13.568 L 88.745 13.568 C 88.581 10.201 86.846 8.141 83.801 8.141 Z M 92.786 8.631 L 92.786 6.474 L 95.241 6.474 L 95.241 1.144 L 97.893 1.144 L 97.893 6.474 L 101.167 6.474 L 101.167 8.631 L 97.893 8.631 L 97.893 19.617 C 97.893 20.794 98.515 21.186 99.595 21.186 C 100.119 21.186 100.708 21.055 101.003 20.957 L 101.101 20.957 L 101.101 23.246 C 100.479 23.377 99.759 23.475 98.973 23.475 C 96.813 23.475 95.241 22.592 95.241 20.205 L 95.241 8.631 Z M 110.322 23.867 C 105.673 23.867 103.086 21.676 102.825 17.884 L 105.542 17.884 C 105.902 20.826 107.866 21.644 110.387 21.644 C 113.17 21.644 114.316 20.434 114.316 18.865 C 114.316 16.968 113.006 16.478 109.896 15.824 C 106.557 15.138 103.578 14.451 103.578 10.756 C 103.578 7.945 105.738 6.114 109.667 6.114 C 113.857 6.114 115.92 8.108 116.313 11.41 L 113.595 11.41 C 113.333 9.187 112.122 8.206 109.601 8.206 C 107.179 8.206 106.197 9.285 106.197 10.626 C 106.197 12.457 107.833 12.816 110.747 13.405 C 114.152 14.091 117 14.843 117 18.734 C 117 22.134 114.217 23.867 110.322 23.867 Z" fill="rgb(229, 89, 36)" height="29px" id="IhqJQ7QHj" width="116.99999539209648px"/></svg>)